Prostate tumor DNA methylation is associated with cigarette smoking and adverse prostate cancer outcomes.

ABSTRACT:

Background

DNA methylation has been hypothesized as a mechanism for explaining the association between smoking and adverse prostate cancer (PCa) outcomes. This study was aimed at assessing whether smoking is associated with prostate tumor DNA methylation and whether these alterations may explain in part the association of smoking with PCa recurrence and mortality.

Methods

A total of 523 men had radical prostatectomy as their primary treatment, detailed smoking history data, long-term follow-up for PCa outcomes, and tumor tissue profiled for DNA methylation. Ninety percent of the men also had matched tumor gene expression data. A methylome-wide analysis was conducted to identify differentially methylated regions (DMRs) by smoking status. To select potential functionally relev

SUBMITTER: Shui IM 

PROVIDER: S-EPMC4930391 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature