Diabetes, prostate cancer screening and risk of low- and high-grade prostate cancer: an 11 year historical population follow-up study of more than 1 million men.

ABSTRACT:

Aims/hypothesis

An inverse association has consistently been shown between diabetes and prostate cancer incidence. We investigated whether lower prostate cancer incidence among men with diabetes is attributable to lower detection due to prostate cancer screening patterns.

Methods

We studied a population-based historical cohort of 1,034,074 Israeli men aged 21-90 years, without a previous history of cancer. The cohort was followed-up from 2002 to 2012, according to diabetes morbidity, for frequency of prostate-specific antigen (PSA) testing, mean PSA values and detection of prostate cancer, after adjustment for age, ethnic origin, socioeconomic status and PSA testing.

Results

In January 2002, 74,756 men had prevalent diabetes. During the 11 year follow-up, 765,483 (74%

SUBMITTER: Dankner R 

PROVIDER: S-EPMC4930460 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature