Loss of BMP receptor type 1A in murine adipose tissue attenuates age-related onset of insulin resistance.

ABSTRACT:

Aims/hypothesis

Adipose tissue dysfunction is a prime risk factor for the development of metabolic disease. Bone morphogenetic proteins (BMPs) have previously been implicated in adipocyte formation. Here, we investigate the role of BMP signalling in adipose tissue health and systemic glucose homeostasis.

Methods

We employed the Cre/loxP system to generate mouse models with conditional ablation of BMP receptor 1A in differentiating and mature adipocytes, as well as tissue-resident myeloid cells. Metabolic variables were assessed by glucose and insulin tolerance testing, insulin-stimulated glucose uptake and gene expression analysis.

Results

Conditional deletion of Bmpr1a using the aP2 (also known as Fabp4)-Cre strain resulted in a complex phenotype. Knockout mice were

SUBMITTER: Schulz TJ 

PROVIDER: S-EPMC4930470 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature