Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens.

ABSTRACT:

Background

Multiple important human and livestock pathogens employ ticks as their primary host vectors. It is not currently known whether this means of infecting a host arose once or many times during evolution.

Results

In order to address this question, we conducted a comparative genomics analysis on a set of bacterial pathogens from seven genera - Borrelia, Rickettsia, Anaplasma, Ehrlichia, Francisella, Coxiella, and Bartonella, including species from three different host vectors - ticks, lice, and fleas. The final set of 102 genomes used in the study encoded a total of 120,046 protein sequences. We found that no genes or metabolic pathways were present in all tick-borne bacteria. However, we found some genes and pathways were present in subsets of tick-transmitted organis

SUBMITTER: Lockwood S 

PROVIDER: S-EPMC4930560 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature