Determinants of FIV and HIV Vif sensitivity of feline APOBEC3 restriction factors.

ABSTRACT:

Background

Feline immunodeficiency virus (FIV) is a global pathogen of Felidae species and a model system for Human immunodeficiency virus (HIV)-induced AIDS. In felids such as the domestic cat (Felis catus), APOBEC3 (A3) genes encode for single-domain A3Z2s, A3Z3 and double-domain A3Z2Z3 anti-viral cytidine deaminases. The feline A3Z2Z3 is expressed following read-through transcription and alternative splicing, introducing a previously untranslated exon in frame, encoding a domain insertion called linker. Only A3Z3 and A3Z2Z3 inhibit Vif-deficient FIV. Feline A3s also are restriction factors for HIV and Simian immunodeficiency viruses (SIV). Surprisingly, HIV-2/SIV Vifs can counteract feline A3Z2Z3.

Results

To identify residues in feline A3s that Vifs need for interaction a

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC4930625 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature