The effects of smoking and smoking cessation on nasal mucociliary clearance, mucus properties and inflammation.

ABSTRACT:

Objective

The aim of the present study was to assess nasal mucociliary clearance, mucus properties and inflammation in smokers and subjects enrolled in a Smoking Cessation Program (referred to as quitters).

Method

A total of 33 subjects with a median (IQR) smoking history of 34 (20-58) pack years were examined for nasal mucociliary clearance using a saccharine transit test, mucus properties using contact angle and sneeze clearability tests, and quantification of inflammatory and epithelial cells, IL-6 and IL-8 concentrations in nasal lavage fluid. Twenty quitters (mean age: 51 years, 9 male) were assessed at baseline, 1 month, 3 months and 12 months after smoking cessation, and 13 smokers (mean age: 52 years, 6 male) were assessed at baseline and after 12 months. Clinicaltri

SUBMITTER: Utiyama DM 

PROVIDER: S-EPMC4930664 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature