Serum Estrogens and Estrogen Metabolites and Endometrial Cancer Risk among Postmenopausal Women.

ABSTRACT:

Background

Although endometrial cancer is clearly influenced by hormonal factors, few epidemiologic studies have investigated the role of endogenous estrogens or especially estrogen metabolites.

Methods

We conducted a nested case-control study within the Women's Health Initiative Observational Study (WHI-OS), a cohort of 93,676 postmenopausal women recruited between 1993 and 1998. Using baseline serum samples from women who were non-current hormone users with intact uteri, we measured 15 estrogens/estrogen metabolites via HPLC/MS-MS among 313 incident endometrial cancer cases (271 type I, 42 type II) and 354 matched controls, deriving adjusted ORs and 95% confidence intervals (CI) for overall and subtype-specific endometrial cancer risk.

Results

Parent estrogens (estr

SUBMITTER: Brinton LA 

PROVIDER: S-EPMC4930692 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature