Early Life Body Fatness, Serum Anti-Mullerian Hormone, and Breast Density in Young Adult Women.

ABSTRACT:

Background

Emerging evidence suggests positive associations between serum anti-Müllerian hormone (AMH), a marker of ovarian function, and breast cancer risk. Body size at young ages may influence AMH levels, but few studies have examined this. Also, no studies have examined the relation of AMH levels with breast density, a strong predictor of breast cancer risk.

Methods

We examined associations of early life body fatness, AMH concentrations, and breast density among 172 women in the Dietary Intervention Study in Children (DISC). Height and weight were measured at baseline (ages 8-10) and throughout adolescence. Serum AMH concentrations and breast density were assessed at ages 25-29 at the DISC 2006 Follow-up visit. We used linear mixed effects models to quantify associations

SUBMITTER: Bertrand KA 

PROVIDER: S-EPMC4930720 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature