Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population.

ABSTRACT:

Purpose

This study evaluated the discriminatory power of salivary transcriptomic and proteomic biomarkers in distinguishing oral squamous cell carcinoma cases from controls and potentially malignant oral disorders (PMOD).

Experimental design

A total of 180 samples (60 OSCC patients, 60 controls, and 60 PMOD patients) were used in the study. Seven transcriptomic markers (IL8, IL1β, SAT1, OAZ1, DUSP1, S100P, and H3F3A) were measured using qPCR, and two proteomic markers (IL8 and IL1β) were evaluated by ELISA.

Results

Among 7 transcriptomic markers, transcript level of DUSP1 was significantly lower in OSCC patients than in controls and PMOD patients. Between the proteomic markers, the protein concentration of IL8 and IL1β was significantly higher in OSCC patients than co

SUBMITTER: Gleber-Netto FO 

PROVIDER: S-EPMC4930722 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature