Exploring the effect of silver nanoparticle size and medium composition on uptake into pulmonary epithelial 16HBE14o-cells.

ABSTRACT: The increasing number of nanotechnology products on the market poses increasing human health risks by particle exposures. Adverse effects of silver nanoparticles (AgNPs) in various cell lines have been measured based on exposure dose after a fixed time point, but NP uptake kinetics and the time-dependent internal cellular concentration are often not considered. Even though knowledge about relevant timescales for NP uptake is essential, e.g. for time- and cost-effective risk assessment through modelling, insufficient data are available. Therefore, the authors examined uptake rates for three different AgNP sizes (20, 50 and 75 nm) and two tissue culture medium compositions (with and without foetal calf serum, FCS) under realistic exposure concentrations in pulmonary epithelial 16HBE14o-cells

SUBMITTER: Kettler K 

PROVIDER: S-EPMC4930793 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature