A key genetic factor for fucosyllactose utilization affects infant gut microbiota development.

ABSTRACT: Recent studies have demonstrated that gut microbiota development influences infants' health and subsequent host physiology. However, the factors shaping the development of the microbiota remain poorly understood, and the mechanisms through which these factors affect gut metabolite profiles have not been extensively investigated. Here we analyse gut microbiota development of 27 infants during the first month of life. We find three distinct clusters that transition towards Bifidobacteriaceae-dominant microbiota. We observe considerable differences in human milk oligosaccharide utilization among infant bifidobacteria. Colonization of fucosyllactose (FL)-utilizing bifidobacteria is associated with altered metabolite profiles and microbiota compositions, which have been previously shown to affe

SUBMITTER: Matsuki T 

PROVIDER: S-EPMC4931012 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature