Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.

ABSTRACT: Technical and biological innovations have enabled the development of more sophisticated and focused murine models that increasingly recapitulate the complex pathologies of human diseases, in particular cancer. Mouse models provide excellent in vivo systems for deciphering the intricacies of cancer biology within the context of precise experimental settings. They present biologically relevant, adaptable platforms that are amenable to continual improvement and refinement. We discuss how recent advances in our understanding of tumorigenesis and the underlying deficiencies of DNA repair mechanisms that drive it have been informed by using genetically engineered mice to create defined, well-characterized models of human colorectal cancer. In particular, we focus on how mechanisms of DNA repair

SUBMITTER: Mcilhatton MA 

PROVIDER: S-EPMC4931062 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature