Anti-inflammatory role of glucose-dependent insulinotropic polypeptide in periodontitis.

ABSTRACT:

Aims/introduction

The involvement of glucose-dependent insulinotropic polypeptide (GIP) on inflammation was explored in atherosclerosis and adipose tissue. Periodontal disease is a chronic inflammatory disease, and is considered one of the diabetic complications. In the present study, to examine the effect of GIP on periodontitis, we induced experimental periodontitis in glucose-dependent insulinotropic polypeptide receptor-knockout mice (GIPRKO). We also investigated the anti-inflammatory effect of GIP in a culture system.

Materials and methods

Experimental periodontitis was induced by ligature wire in GIPRKO and C57BL/C mice. Two weeks after the ligature, immunohistological evaluation and inflammatory messenger ribonucleic acid expression in the gingiva was examined. To el

SUBMITTER: Suzuki Y 

PROVIDER: S-EPMC4931199 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature