Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer.

ABSTRACT: Biomarkers are rapidly gaining importance in personalized medicine. Although numerous molecular signatures have been developed over the past decade, there is a lack of overlap and many biomarkers fail to validate in independent patient cohorts and hence are not useful for clinical application. For these reasons, identification of novel and robust biomarkers remains a formidable challenge. We combine targeted proteomics with computational biology to discover robust proteomic signatures for prostate cancer. Quantitative proteomics conducted in expressed prostatic secretions from men with extraprostatic and organ-confined prostate cancers identified 133 differentially expressed proteins. Using synthetic peptides, we evaluate them by targeted proteomics in a 74-patient cohort of expressed pros

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4931234 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature