Ontology highlight
ABSTRACT:
SUBMITTER: Lee DH
PROVIDER: S-EPMC4931324 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Nature communications 20160630
The Hippo pathway regulates the self-renewal and differentiation of various adult stem cells, but its role in cell fate determination and differentiation during liver development remains unclear. Here we report that the Hippo pathway controls liver cell lineage specification and proliferation separately from Notch signalling, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the direct upstream regulators of YAP and TAZ. During and after liver developmen ...[more]