Stress Regulates Aquaporin-8 Permeability to Impact Cell Growth and Survival.

ABSTRACT:

Unlabelled

Aquaporin-8 (AQP8) allows the bidirectional transport of water and hydrogen peroxide across biological membranes. Depending on its concentration, H2O2 exerts opposite roles, amplifying growth factor signaling in physiological conditions, but causing severe cell damage when in excess. Thus, H2O2 permeability is likely to be tightly controlled in living cells.

Aims

In this study, we investigated whether and how the transport of H2O2 through plasma membrane AQP8 is regulated, particularly during cell stress.

Results

We show that diverse cellular stress conditions, including heat, hypoxia, and ER stress, reversibly inhibit the permeability of AQP8 to H2O2 and water. Preventing the accumulation of intracellular reactive oxygen species (ROS) during stress counter

SUBMITTER: Medrano-Fernandez I 

PROVIDER: S-EPMC4931348 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature