Pre-existing diabetes and lung cancer prognosis.

ABSTRACT:

Background

The aims of this study are to investigate the impact of pre-existing diabetes and diabetes treatments on lung cancer prognosis.

Methods

A total of 2484 women with confirmed incident lung cancer from the Women's Health Initiative were followed for an average of 2.9 years through the date of death or 29 August 2014.

Results

Compared with women with lung cancer but without diabetes, women with lung cancer and diabetes had significantly increased risk of overall mortality (HR=1.27, 95% CI: 1.07-1.50). Women with diabetes receiving insulin or metformin or women who had long duration of diabetes also had increased risk of overall mortality.

Conclusions

Our large prospective study provides evidence that pre-existing diabetes is associated with poor overall

SUBMITTER: Luo J 

PROVIDER: S-EPMC4931364 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature