Statin use and all-cancer survival: prospective results from the Women's Health Initiative.

ABSTRACT:

Background

This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT).

Methods

The WHI study enrolled women aged 50-79 years from 1993 to 1998 at 40 US clinical centres. Among 146 326 participants with median 14.6 follow-up years, 23 067 incident cancers and 3152 cancer deaths were observed. Multivariable-adjusted Cox proportional hazards models were used to investigate the relationship between statin use and cancer survival.

Results

Compared with never-users, current statin use was associated with significantly lower risk of cancer death (hazard ratio (HR), 0.78; 95% confidence interval

SUBMITTER: Wang A 

PROVIDER: S-EPMC4931370 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature