Association between prediagnostic glucose, triglycerides, cholesterol and meningioma, and reverse causality.

ABSTRACT:

Background

Although meningioma is a benign tumour, it may cause significant morbidity. Obesity and diabetes are positively associated with meningioma. To evaluate the potential effects of obesity-related prediagnostic glucose, triglycerides and cholesterol on meningioma and of prediagnostic meningioma on these biomarkers, we conducted a cohort study.

Methods

We identified 41 355 individuals in the Apolipoprotein MOrtality RISk cohort with values for these biomarkers within 15 years before meningioma diagnosis, death, migration or the end of follow-up. We then estimated hazard ratios (HRs) and their interactions with time and age using Cox regression.

Results

Meningioma was diagnosed in 181 women and 115 men whose median follow-up time was 7 years. Fasting serum glucos

SUBMITTER: Bernardo BM 

PROVIDER: S-EPMC4931373 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature