Ontology highlight
ABSTRACT:
SUBMITTER: Moravec M
PROVIDER: S-EPMC4931564 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Moravec Martin M Wischnewski Harry H Bah Amadou A Hu Yan Y Liu Na N Lafranchi Lorenzo L King Megan C MC Azzalin Claus M CM
EMBO reports 20160506 7
Telomerase-mediated telomere elongation provides cell populations with the ability to proliferate indefinitely. Telomerase is capable of recognizing and extending the shortest telomeres in cells; nevertheless, how this mechanism is executed remains unclear. Here, we show that, in the fission yeast Schizosaccharomyces pombe, shortened telomeres are highly transcribed into the evolutionarily conserved long noncoding RNA TERRA A fraction of TERRA produced upon telomere shortening is polyadenylated ...[more]