RNA is an Adjuvanticity Mediator for the Lipid-Based Mucosal Adjuvant, Endocine.

ABSTRACT: Nasal vaccination has the potential to elicit systemic and mucosal immunity against pathogens. However, split and subunit vaccines lack potency at stimulating mucosal immunity, and an adjuvant is indispensable for eliciting potent mucosal immune response to nasal vaccines. Endocine, a lipid-based mucosal adjuvant, potentiates both systemic and mucosal immune responses. Although Endocine has shown efficacy and tolerability in animal and clinical studies, its mechanism of action remains unknown. It has been reported recently that endogenous danger signals are essential for the effects of some adjuvants such as alum or MF59. However, the contribution of danger signals to the adjuvanticity of Endocine has not been explored. Here, we show that RNA is likely to be an important mediator for the a

SUBMITTER: Hayashi M 

PROVIDER: S-EPMC4931589 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature