Disentangling the autism-anxiety overlap: fMRI of reward processing in a community-based longitudinal study.

ABSTRACT: Up to 40% of youth with autism spectrum disorder (ASD) also suffer from anxiety, and this comorbidity is linked with significant functional impairment. However, the mechanisms of this overlap are poorly understood. We investigated the interplay between ASD traits and anxiety during reward processing, known to be affected in ASD, in a community sample of 1472 adolescents (mean age=14.4 years) who performed a modified monetary incentive delay task as part of the Imagen project. Blood-oxygen-level dependent (BOLD) responses to reward anticipation and feedback were compared using a 2x2 analysis of variance test (ASD traits: low/high; anxiety symptoms: low/high), controlling for plausible covariates. In addition, we used a longitudinal design to assess whether neural responses during reward pro

SUBMITTER: Mikita N 

PROVIDER: S-EPMC4931605 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature