Higher reward value of starvation imagery in anorexia nervosa and association with the Val66Met BDNF polymorphism.

ABSTRACT: Recent studies support the idea that abnormalities of the reward system contribute to onset and maintenance of anorexia nervosa (AN). Next to cues coding for overweight, other research suggest cues triggering the proposed starvation dependence to be pivotally involved in the AN pathogenesis. We assessed the characteristics of the cognitive, emotional and physiologic response toward disease-specific pictures of female body shapes, in adult AN patients compared with healthy control (HC) women. Frequency and amplitude of skin conductance response (SCR) in 71 patients with AN and 20 HC were registered during processing of stimuli of three weight categories (over-, under- and normal weight). We then assessed the role of the Val66Met BDNF polymorphism as a potential intermediate factor. AN patie

SUBMITTER: Clarke J 

PROVIDER: S-EPMC4931615 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature