S100A4 in Cancer Metastasis: Wnt Signaling-Driven Interventions for Metastasis Restriction.

ABSTRACT: The aberrant activity of Wnt signaling is an early step in the transformation of normal intestinal cells to malignant tissue, leading to more aggressive tumors, and eventually metastases. In colorectal cancer (CRC), metastasis accounts for about 90% of patient deaths, representing the most lethal event during the course of the disease and is directly linked to patient survival, critically limiting successful therapy. This review focuses on our studies of the metastasis-inducing gene S100A4, which we identified as transcriptional target of β-catenin. S100A4 increased migration and invasion in vitro and metastasis in mice. In patient CRC samples, high S100A4 levels predict metastasis and reduced patient survival. Our results link pathways important for tumor progression and metastasis: the W

SUBMITTER: Dahlmann M 

PROVIDER: S-EPMC4931624 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature