Implementation of a Zebrafish Health Program in a Research Facility: A 4-Year Retrospective Study.

ABSTRACT: In the past two decades, zebrafish (Danio rerio)-based research has contributed to significant scientific advances. Still, husbandry and health programs did not evolve at the same pace, as evidenced by the absence of general guidelines. Health monitoring is essential to animal welfare, to permit animal exchanges across facilities, to contribute to robust experimental results, and for data reproducibility. In this study, we report a health program implemented in a zebrafish research facility to prevent, monitor, and control pathogen, and disease dissemination. This program includes quarantine, routine health screening of sentinels, and nonroutine screenings of retired animals and sick/moribund individuals. An extensive list of clinical signs, lesions, and pathogens was monitored based on: d

SUBMITTER: Borges AC 

PROVIDER: S-EPMC4931741 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature