HIV Drug Resistance Among Children Initiating First-Line Antiretroviral Treatment in Uganda.

ABSTRACT:

Background

There are limited data on primary human immunodeficiency virus drug resistance (HIVDR) in pediatric populations. This study aimed to assess the prevalence of primary HIVDR and associated risk factors among children initiating first-line antiretroviral therapy (ART) in Uganda.

Methods

At three Ugandan clinics, children (age <12 years) requiring ART were recruited between January 2010 and August 2011. Before starting ART, blood was collected for viral load and pol gene sequencing. Drug resistance mutations were determined using the 2010 International AIDS Society-USA mutation list. Risk factors for HIVDR were assessed with multivariate regression analysis.

Results

Three hundred nineteen HIV-infected children with a median age of 4.9 years were enrolled. Seque

SUBMITTER: Kityo C 

PROVIDER: S-EPMC4931746 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature