Ischemic stroke induces gut permeability and enhances bacterial translocation leading to sepsis in aged mice.

ABSTRACT: Aging is an important risk factor for post-stroke infection, which accounts for a large proportion of stroke-associated mortality. Despite this, studies evaluating post-stroke infection rates in aged animal models are limited. In addition, few studies have assessed gut microbes as a potential source of infection following stroke. Therefore we investigated the effects of age and the role of bacterial translocation from the gut in post-stroke infection in young (8-12 weeks) and aged (18-20 months) C57Bl/6 male mice following transient middle cerebral artery occlusion (MCAO) or sham surgery. Gut permeability was examined and peripheral organs were assessed for the presence of gut-derived bacteria following stroke. Furthermore, sickness parameters and components of innate and adaptive immunity

SUBMITTER: Crapser J 

PROVIDER: S-EPMC4931853 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature