Accelerated ageing and renal dysfunction links lower socioeconomic status and dietary phosphate intake.

ABSTRACT:

Background

We have sought to explore the impact of dietary Pi intake on human age related health in the pSoBid cohort (n=666) to explain the disparity between health and deprivation status in this cohort. As hyperphosphataemia is a driver of accelerated ageing in rodent models of progeria we tested whether variation in Pi levels in man associate with measures of biological ageing and health.

Results

We observed significant relationships between serum Pi levels and markers of biological age (telomere length (p=0.040) and DNA methylation content (p=0.028), gender and chronological age (p=0.032). When analyses were adjusted for socio-economic status and nutritional factors, associations were observed between accelerated biological ageing (telomere length, genomic methylation co

SUBMITTER: McClelland R 

PROVIDER: S-EPMC4931858 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature