Thiopurine S-methyltransferase testing for averting drug toxicity in patients receiving thiopurines: a systematic review.

ABSTRACT:

Aim

Thiopurine S-methyltransferase (TPMT) testing is used in patients receiving thiopurines to identify enzyme deficiencies and risk for adverse drug reactions. It is uncertain whether genotyping is superior to phenotyping. The objectives were to conduct a systematic review of TPMT-test performance studies.

Materials & methods

Electronic and grey literature sources were searched for studies reporting test performance compared with a reference standard. Sixty-six eligible studies were appraised for quality.

Results

Thirty phenotype-genotype and six phenotype-phenotype comparisons were of high quality. The calculated sensitivity and specificity for genotyping to identify a homozygous mutation ranged from 0.0-100.0% and from 97.8-100.0%, respectively.

Conclusion

C

SUBMITTER: Roy LM 

PROVIDER: S-EPMC4931919 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature