Predicting Survival in Dementia With Lewy Bodies With Hippocampal Volumetry.

ABSTRACT:

Background

The clinical course of dementia with Lewy bodies patients is heterogeneous. The ability to more accurately prognosticate survival is important.

Objective

The objective of this study was to investigate hippocampal volume as a predictor of survival in dementia with Lewy bodies patients.

Methods

Survival analysis for time from onset of cognitive symptoms to death was carried out using Cox proportional hazards models. Given their age and total intracranial volume, patients were dichotomized into low/medium (0%-66.7%) and high (66. 7%-100%) hippocampal volume categories. The models using these categories to predict survival were adjusted for field strength, APOE ε4 status, and estimated onset age of cognitive problems.

Results

We investigated 167 consecut

SUBMITTER: Graff-Radford J 

PROVIDER: S-EPMC4931944 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature