Serum 25-hydroxyvitamin D concentrations in Mid-adulthood and Parkinson's disease risk.

ABSTRACT:

Background

Low vitamin D levels are common among patients with Parkinson's disease (PD). Experimental evidence further suggests that vitamin D may be protective against PD. The objective of this study was to prospectively assess the association between serum 25-hydroxyvitamin D and PD among 12,762 participants of the Atherosclerosis Risk in Communities Study cohort.

Methods

Serum samples were collected in 1990-1992, and 25-hydroxyvitamin D was measured by liquid chromatography mass spectrometry. A total of 67 incident PD cases were identified through December 31, 2008. The median length of follow-up was 17 years. We used Cox proportional hazards models to obtain hazard ratios and 95% confidence intervals, adjusting for age, sex, and race. We did not find any association betw

SUBMITTER: Shrestha S 

PROVIDER: S-EPMC4931952 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature