A haplotype method detects diverse scenarios of local adaptation from genomic sequence variation.

ABSTRACT: Identifying genomic targets of population-specific positive selection is a major goal in several areas of basic and applied biology. However, it is unclear how often such selection should act on new mutations versus standing genetic variation or recurrent mutation, and furthermore, favoured alleles may either become fixed or remain variable in the population. Very few population genetic statistics are sensitive to all of these modes of selection. Here, we introduce and evaluate the Comparative Haplotype Identity statistic (χMD ), which assesses whether pairwise haplotype sharing at a locus in one population is unusually large compared with another population, relative to genomewide trends. Using simulations that emulate human and Drosophila genetic variation, we find that χMD is sensitive

SUBMITTER: Lange JD 

PROVIDER: S-EPMC4931985 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature