Imaging in-vivo tau pathology in Alzheimer's disease with THK5317 PET in a multimodal paradigm.

ABSTRACT:

Purpose

The aim of this study was to explore the cerebral distribution of the tau-specific PET tracer [(18)F]THK5317 (also known as (S)-[(18)F]THK5117) retention in different stages of Alzheimer's disease; and study any associations with markers of hypometabolism and amyloid-beta deposition.

Methods

Thirty-three individuals were enrolled, including nine patients with Alzheimer's disease dementia, thirteen with mild cognitive impairment (MCI), two with non-Alzheimer's disease dementia, and nine healthy controls (five young and four elderly). In a multi-tracer PET design [(18)F]THK5317, [(11)C] Pittsburgh compound B ([(11)C]PIB), and [(18)F]FDG were used to assess tau pathology, amyloid-beta deposition and cerebral glucose metabolism, respectively. The MCI patients were furthe

SUBMITTER: Chiotis K 

PROVIDER: S-EPMC4932128 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature