Genomic diversity of colorectal cancer: Changing landscape and emerging targets.

ABSTRACT: Improvements in screening and preventive measures have led to an increased detection of early stage colorectal cancers (CRC) where patients undergo treatment with a curative intent. Despite these efforts, a high proportion of patients are diagnosed with advanced stage disease that is associated with poor outcomes, as CRC remains one of the leading causes of cancer-related deaths in the world. The development of next generation sequencing and collaborative multi-institutional efforts to characterize the cancer genome has afforded us with a comprehensive assessment of the genomic makeup present in CRC. This knowledge has translated into understanding the prognostic role of various tumor somatic variants in this disease. Additionally, the awareness of the genomic alterations present in CRC ha

SUBMITTER: Ahn DH 

PROVIDER: S-EPMC4932204 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature