Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.

ABSTRACT: The role of the orbitofrontal cortex (OFC) in value processing is a focus of research. Conventional imaging analysis, where smoothing and averaging are employed, may not be sufficiently sensitive in studying the OFC, which has heterogeneous anatomical structures and functions. In this study, we employed representational similarity analysis (RSA) to reveal the multi-voxel fMRI patterns in the OFC associated with value processing during the anticipatory and the consummatory phases. We found that multi-voxel activation patterns in the OFC encoded magnitude and partial valence information (win vs. loss) but not outcome (favourable vs. unfavourable) during reward consummation. Furthermore, the lateral OFC rather than the medial OFC encoded loss information. Also, we found that OFC encoded value

SUBMITTER: Yan C 

PROVIDER: S-EPMC4932626 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature