PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.

ABSTRACT: Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent infection to active tuberculosis. Among those with latent tuberculosis, it is now recognized that there is also a spectrum of infection and this likely contributes to the variable risk of reactivation tuberculosis. Here, functional imaging with 18F-fluorodeoxygluose positron emission tomography and computed tomography (PET CT) of cynomolgus macaques with latent M. tuberculosis infection was used to characterize the features of reactivation after tumor necrosis factor (TNF) neutralization and determine which imaging characteristics before TNF neutralization distinguish reactivation risk. PET CT was performed on latently infected macaques (n = 26) before and during the course of TNF neutralization and a se

SUBMITTER: Lin PL 

PROVIDER: S-EPMC4933353 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature