Novel approaches to pulmonary arterial hypertension drug discovery.

ABSTRACT:

Introduction

Pulmonary arterial hypertension (PAH) is a rare disorder associated with abnormally elevated pulmonary pressures that, if untreated, leads to right heart failure and premature death. The goal of drug development for PAH is to develop effective therapies that halt, or ideally, reverse the obliterative vasculopathy that results in vessel loss and obstruction of blood flow to the lungs.

Areas covered

This review summarizes the current approach to candidate discovery in PAH and discusses the currently available drug discovery methods that should be implemented to prioritize targets and obtain a comprehensive pharmacological profile of promising compounds with well-defined mechanisms.

Expert opinion

To improve the successful identification of leading drug cand

SUBMITTER: Sung YK 

PROVIDER: S-EPMC4933595 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature