Combining targeted therapy with immunotherapy. Can 1+1 equal more than 2?

ABSTRACT: Targeted therapies have induced high response rates and improved survival in patients with cancer. However, the long-term effectiveness of targeted therapies has been limited by the development of acquired resistance in the majority of patients. On the other hand, the modern immunotherapy strategies have been associated with durable responses but in limited number of patients. Accordingly, research efforts have been focused on examining the effects of combinations of targeted therapy and immunotherapy in several different histological subtypes of cancer. There has been accumulated evidence to suggest that targeted therapy can induce immune effects in the tumor cells, the host immune system, and the tumor microenvironment. Subsequently, clinical trials have been designed to examine the effi

SUBMITTER: Robert L 

PROVIDER: S-EPMC4933650 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature