Oral pigmentation in McCune-Albright syndrome.

ABSTRACT:

Importance

The differential diagnosis for oral lentigines includes several syndromes with important associated systemic findings. McCune-Albright syndrome (MAS), a mosaic condition associated with café au lait pigmentation, is not typically considered a mucosal lentiginosis syndrome. The clinical phenotype of MAS is variable because of mosaicism, but oral pigmentation developing in mid-childhood to early adulthood should be recognized as a clinical feature of MAS.

Observations

We present 4 patients with MAS who developed oral mucosal pigmentation during childhood or early adulthood. All patients had other characteristic findings of MAS including hyperfunctioning endocrinopathies, polyostotic fibrous dysplasia, and café au lait pigmentation.

Conclusions and relevance

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SUBMITTER: Pichard DC 

PROVIDER: S-EPMC4933654 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature