Comparative idiosyncrasies in life extension by reduced mTOR signalling and its distinctiveness from dietary restriction.

ABSTRACT: Reduced mechanistic target of rapamycin (mTOR) signalling extends lifespan in yeast, nematodes, fruit flies and mice, highlighting a physiological pathway that could modulate aging in evolutionarily divergent organisms. This signalling system is also hypothesized to play a central role in lifespan extension via dietary restriction. By collating data from 48 available published studies examining lifespan with reduced mTOR signalling, we show that reduced mTOR signalling provides similar increases in median lifespan across species, with genetic mTOR manipulations consistently providing greater life extension than pharmacological treatment with rapamycin. In contrast to the consistency in changes in median lifespan, however, the demographic causes for life extension are highly species specifi

SUBMITTER: Garratt M 

PROVIDER: S-EPMC4933670 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature