Secreted microvesicular miR-31 inhibits osteogenic differentiation of mesenchymal stem cells.

ABSTRACT: Damage to cells and tissues is one of the driving forces of aging and age-related diseases. Various repair systems are in place to counteract this functional decline. In particular, the property of adult stem cells to self-renew and differentiate is essential for tissue homeostasis and regeneration. However, their functionality declines with age (Rando, 2006). One organ that is notably affected by the reduced differentiation capacity of stem cells with age is the skeleton. Here, we found that circulating microvesicles impact on the osteogenic differentiation capacity of mesenchymal stem cells in a donor-age-dependent way. While searching for factors mediating the inhibitory effect of elderly derived microvesicles on osteogenesis, we identified miR-31 as a crucial component. We demonstrated

SUBMITTER: Weilner S 

PROVIDER: S-EPMC4933673 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature