Exploring Instructive Physiological Signaling with the Bioelectric Tissue Simulation Engine.

ABSTRACT: Bioelectric cell properties have been revealed as powerful targets for modulating stem cell function, regenerative response, developmental patterning, and tumor reprograming. Spatio-temporal distributions of endogenous resting potential, ion flows, and electric fields are influenced not only by the genome and external signals but also by their own intrinsic dynamics. Ion channels and electrical synapses (gap junctions) both determine, and are themselves gated by, cellular resting potential. Thus, the origin and progression of bioelectric patterns in multicellular tissues is complex, which hampers the rational control of voltage distributions for biomedical interventions. To improve understanding of these dynamics and facilitate the development of bioelectric pattern control strategies, we

SUBMITTER: Pietak A 

PROVIDER: S-EPMC4933718 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature