Identification of the anti-tumor activity and mechanisms of nuciferine through a network pharmacology approach.

ABSTRACT:

Aim

Nuciferine is an aporphine alkaloid extracted from lotus leaves, which is a raw material in Chinese medicinal herb for weight loss. In this study we used a network pharmacology approach to identify the anti-tumor activity of nuciferine and the underlying mechanisms.

Methods

The pharmacological activities and mechanisms of nuciferine were identified through target profile prediction, clustering analysis and functional enrichment analysis using our traditional Chinese medicine (TCM) network pharmacology platform. The anti-tumor activity of nuciferine was validated by in vitro and in vivo experiments. The anti-tumor mechanisms of nuciferine were predicted through network target analysis and verified by in vitro experiments.

Results

The nuciferine target profile was e

SUBMITTER: Qi Q 

PROVIDER: S-EPMC4933762 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature