Uptake, outcomes, and costs of implementing non-invasive prenatal testing for Down's syndrome into NHS maternity care: prospective cohort study in eight diverse maternity units.

ABSTRACT:

Objective

 To investigate the benefits and costs of implementing non-invasive prenatal testing (NIPT) for Down's syndrome into the NHS maternity care pathway.

Design

 Prospective cohort study.

Setting

 Eight maternity units across the United Kingdom between 1 November 2013 and 28 February 2015.

Participants

 All pregnant women with a current Down's syndrome risk on screening of at least 1/1000.

Main outcome measures

 Outcomes were uptake of NIPT, number of cases of Down's syndrome detected, invasive tests performed, and miscarriages avoided. Pregnancy outcomes and costs associated with implementation of NIPT, compared with current screening, were determined using study data on NIPT uptake and invasive testing in combination with national datasets.

Res

SUBMITTER: Chitty LS 

PROVIDER: S-EPMC4933930 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature