Dinosaur: A Refined Open-Source Peptide MS Feature Detector.

ABSTRACT: In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of chimeric spectra or sample complexity characterization. Feature detection is difficult because of the high complexity of MS proteomics data from biological samples, which frequently causes features to intermingle. In addition, existing feature detection algorithms commonly suffer from compatibility issues, long computation times, or poor performance on high-resolution data. Because of these limitations, we developed a new tool, Dinosaur, with increased speed and versatility. Dinosaur has the functionality to sample algorithm computations through

SUBMITTER: Teleman J 

PROVIDER: S-EPMC4933939 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature