Palladium-Catalyzed, Enantioselective Heine Reaction.

ABSTRACT: Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine reaction. The first catalytic, enantioselective Heine reaction is reported for meso-N-acylaziridines where a palladium(II)-diphosphine complex is employed. The highly enantioenriched oxazoline products are valuable organic synthons and potential ligands for transition-metal catalysis.

SUBMITTER: Punk M 

PROVIDER: S-EPMC4933940 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature