Near-infrared luminescent CaTiO₃:Nd³⁺ nanofibers with tunable and trackable drug release kinetics.

ABSTRACT: 750-850 nm (NIR I) and 1000-1400 nm (NIR II) in the near infrared (NIR) spectra are two windows of optical transparency for biological tissues with the latter capable of penetrating tissue deeper. Monitoring drug release from the drug carrier is still a daunting challenge in the field of nanomedicine. To overcome such a challenge, we propose to use porous Nd³⁺-doped CaTiO₃ nanofibers, which can be excited by NIR I to emit NIR II light, to carry drugs to test the concept of monitoring drug release from the nanofibers by detecting the NIR II emission intensity. Towards this end, we first used electrospinning to prepare porous Nd³⁺-doped CaTiO₃ nanofibers by adding micelle-forming surfactant Pluronic F127, followed by annealing to remove the organic

SUBMITTER: Li X 

PROVIDER: S-EPMC4934121 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature