Divergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression.

ABSTRACT:

Objective

Although the average depressed patient benefits moderately from cognitive-behavioral therapy (CBT) or pharmacotherapy, some experience divergent outcomes. The authors tested frequencies, predictors, and moderators of negative and unusually positive outcomes.

Method

Sixteen randomized clinical trials comparing CBT and pharmacotherapy for unipolar depression in 1,700 patients provided individual pre- and posttreatment scores on the Hamilton Depression Rating Scale (HAM-D) and/or Beck Depression Inventory (BDI). The authors examined demographic and clinical predictors and treatment moderators of any deterioration (increase ≥1 HAM-D or BDI point), reliable deterioration (increase ≥8 HAM-D or ≥9 BDI points), extreme nonresponse (posttreatment HAM-D score ≥21 or BDI scor

SUBMITTER: Vittengl JR 

PROVIDER: S-EPMC4934129 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature