Hyperfractionated or accelerated radiotherapy in lung cancer: an individual patient data meta-analysis.

ABSTRACT:

Purpose

In lung cancer, randomized trials assessing hyperfractionated or accelerated radiotherapy seem to yield conflicting results regarding the effects on overall (OS) or progression-free survival (PFS). The Meta-Analysis of Radiotherapy in Lung Cancer Collaborative Group decided to address the role of modified radiotherapy fractionation.

Material and methods

We performed an individual patient data meta-analysis in patients with nonmetastatic lung cancer, which included trials comparing modified radiotherapy with conventional radiotherapy.

Results

In non-small-cell lung cancer (NSCLC; 10 trials, 2,000 patients), modified fractionation improved OS as compared with conventional schedules (hazard ratio [HR] = 0.88, 95% CI, 0.80 to 0.97; P = .009), resulting in an absol

SUBMITTER: Mauguen A 

PROVIDER: S-EPMC4934452 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature