FastRNABindR: Fast and Accurate Prediction of Protein-RNA Interface Residues.

ABSTRACT: A wide range of biological processes, including regulation of gene expression, protein synthesis, and replication and assembly of many viruses are mediated by RNA-protein interactions. However, experimental determination of the structures of protein-RNA complexes is expensive and technically challenging. Hence, a number of computational tools have been developed for predicting protein-RNA interfaces. Some of the state-of-the-art protein-RNA interface predictors rely on position-specific scoring matrix (PSSM)-based encoding of the protein sequences. The computational efforts needed for generating PSSMs severely limits the practical utility of protein-RNA interface prediction servers. In this work, we experiment with two approaches, random sampling and sequence similarity reduction, for extr

SUBMITTER: El-Manzalawy Y 

PROVIDER: S-EPMC4934694 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature